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Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community.
Job Summary
Lead the design, development, and validation of a next-generation ultrasensitive immunoassay platform for early biomarker detection, working closely with the Principal Investigator (PI) to define research direction, experimental strategy, and translational applications.
Essential Job Duties
Lead design and optimization of dual-amplification assay systems.
Plan and execute experimental validation using recombinant proteins and complex biological samples (e.g., human serum).
Develop and implement novel molecular amplification and detection strategies.
Analyze, interpret, and guide quantitative data analysis, including assay performance metrics and modeling.
Collaborate with the PI and external clinical/research partners to support translational objectives.
Contribute to manuscripts, presentations, and grant development.
Basic Qualifications
PhD in Neuroscience, Biochemistry, Molecular Biology, or a related field.
Minimum of 8 years of relevant scientific experience.
Extensive experience in the design, development, and optimization of antibody-based protein detection assays.
Demonstrated expertise in developing and optimizing high-sensitivity detection platforms for low-abundance targets in complex biological matrices.
Strong background in molecular biology techniques and biochemical assay development.
Proven experience with complex, multi-step assay workflows requiring careful optimization of signal-to-background ratio, specificity, and dynamic range.
Strong quantitative and analytical skills, including experience with signal normalization, background correction, and assay reproducibility analysis.
Experience working in interdisciplinary research environments and collaborating across academic and translational settings.
Demonstrated ability to independently lead research projects and develop experimental strategies from concept through validation.
Experience working with automated staining or assay processing platforms, including optimization for reproducibility, robustness, and scalability across experimental runs.
Preferred Qualifications
Background in biomarker assay development for clinical or translational research applications.
Experience optimizing assay performance in complex biological matrices (e.g., serum or plasma), including sensitivity, specificity, and reproducibility.
Experience developing or refining assay workflows intended for broader adoption across research or preclinical settings.
Demonstrated ability to bridge early-stage method development with downstream validation and application.
Track record of innovation in assay development or molecular detection technologies, including contributions to publications, protocols, or platform development.
Experience working in early-stage or startup environments, with demonstrated ability to develop and translate emerging assay technologies from concept to application.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
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The California Institute of Technology (Caltech) is a world-renowned science and engineering research and education institution, where extraordinary faculty and students seek answers to complex questions, discover new knowledge, lead innovation, and transform our future.
