The Stanford Brain Organogenesis Program within the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine is seeking a highly motivated Life Science Research Professional 2 to join Dr. Sergiu Pasca's research program in a 2-year fixed term role.
Our Stanford research team seeks to understand the rules that govern the molecular and cellular steps underlying the assembly of the human brain and the molecular mechanisms that lead to neurodevelopmental and neurodegenerative disorders. We are developing bottom-up approaches to generate and assemble, from multi-cellular components, human neural circuits. More specifically, we have pioneered the generation from human pluripotent stem cells of brain region-specific organoids (Nature Methods 2015; Neuron 2017; Nature Methods 2019; Nature Neuroscience 2019) and assembloids (Nature 2017; Nature Biotechnology 2020; Cell 2020), which we applied to gain mechanistic insights into disease (Nature Medicine 2018; Nature Medicine 2020). Our ultimate goal is to identify novel and reliable drug targets for neuropsychiatric disorders.
The candidate for this position will join an enthusiastic and multi-disciplinary team at Stanford, and should ideally have experience with human stem cells, neural differentiation, primary tissue culture or assay development and high-throughput screens.
For more information on the Pasca lab and research being performed please visit their website at www.pascalab.org.
Independently conduct a portion of the research project(s) related to building brain organoid and assembloid models. Make recommendations on experimental design and/or research direction to principal investigator.
Independently conduct experiments (cell culture, assay, screens) to gather data for a portion of a major research project.
Interpret and analyze results, often where few guidelines exist, and make modifications to existing procedures and protocols.
Participate in multidisciplinary teams across different faculties or schools.
Perform ongoing literature review to remain current with new procedures and related research; apply to ongoing research and development of new protocols.
Contribute substantively to the preparation of papers for publication, especially in the results section, and to publication of findings. Present ongoing work to colleagues and/or academic conferences.
Oversee supply and equipment budget under supervision of principal investigator or business manager.
Work with health and safety department to ensure lab complies with regulations and all required trainings.
Supervise (either formally or informally) staff or students as needed, including oversight and direction on techniques, as well as consultation on project work. Serve as a technical resource for other research staff.
Oversee the daily activities of the laboratory including lab maintenance; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed. May assist with purchasing laboratory equipment.
*- Other duties may also be assigned
Knowledge and experience with neurobiology, stem cell biology, molecular biology techniques and cellular assays
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field and two years of relevant work experience; or Master's degree in a related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
Comprehensive understanding of scientific principles.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Strong analytical skills and excellent judgment.
Ability to maintain detailed records of experiments and outcomes.
Ability to work under deadlines with general guidance is essential.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors bases on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu.
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 12000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford is an equal empl...oyment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University’s research, teaching and clinical missions.