The Keck School of Medicine, department of Pathology is seeking to hire a Postdoctoral Research Associate for a highly motivated fellow to explore the new frontier of bioelectricity in tissue development and regeneration.
Role of bioelectricity in skin morphogenesis. This is a newly funded multi-disciplinary project among Drs. Cheng Ming Chuong, Randall Widelitz, and Robert Chow, University of Southern California, Los Angeles. Lab website: https://sites.usc.edu/cmchuong/
To study roles of non-neural bioelectricity in tissue morphogenesis and pattern formation, we use developing chicken skin and a regenerating feather follicle model. A combination of next-gen sequencing, molecular cloning, lentivirus-mediated gene mis-expression, confocal microscopy, 4D cell behavior movies, and electrophysiology will be used to identify roles of ion channels and gap junctions in morphogenesis. It is a great opportunity to learn multi-disciplinary approaches from three PIs and be a front runner of a new field.
(1) Coupling bioelectric signaling with biochemical signaling. See Li et al. Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks. Nat Commun 9: 5377, 2018. Calcium channel activities passing through gap junctions work with Shh/Wnt to control collective dermal cell movement.
(2) One fundamental issue is how patterns form across the body. Pigment provides a great read out to analyze the pattern. See Inaba et al. Instructive role of melanocytes during pigment pattern formation of the avian skin. PNAS 116: 684, 2019. Melanocyte progenitors form periodic patterns of differentiated melanocytes autonomously in a gap junction-dependent manner.
This is a Grant Funded position
Fixed Term: 12 months, renewable on the recommendation of the faculty mentor and at the discretion of the dean. May be renewed up to a maximum of five years.
Salary: $58,240 per year
Required: CV and a minimum of 3 References attached to application.
Minimum Education:Ph.D. or equivalent doctorate within previous five yearsMinimum Experience:0-1 yearMinimum Field of Expertise:Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods. Strong background in computer programming, mathematical modeling is required.Preferred Education:Preferred Experience:Preferred Field of Expertise:Publications in peer-reviewed journals in the same or related field.
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