The Department of Cell Biology and Human Anatomy at the University of California, Davis, School of Medicine, seeks to hire a full-time employee as a Junior Specialist in Dr. Tom Glaser's lab. This employee will participate in interdisciplinary studies exploring vertebrate eye development, transcription factor action, retinoid (vitamin A) signaling, and the causes of human birth defects. The Specialist will work as part of a team - creatively performing experiments that involve genetics, mouse models, mammalian cell culture, molecular biology, immunohistochemistry, and biochemistry.
Successful candidates are expected to participate in three major categories of activities listed below:
1. RESEARCH (80% EFFORT) The Specialist is expected to work closely with the Principal Investigator (PI) to plan and execute experiments involving molecular cloning, protein biochemistry, mammalian cell culture, mutant and transgenic mouse models, mRNA analysis, immunohistochemistry, confocal microscopy, advanced PCR methods, and human genomic analysis. With assistance from the PI, the Specialist is expected to assist in performing research projects with limited direct guidance, understanding that results from these projects will lead to publication. Therefore, the Specialist should have the skills and/or aptitude needed to generate high-quality data. S/he is also expected to study relevant journal articles, think critically and creatively, and use these resources productively to design experiments and test hypotheses.
In addition to hands-on experimental work, the Specialist's responsibilities include critically interpreting laboratory data and relevant scientific literature; keeping detailed and orderly laboratory notes; curating stocks and electronic data (digital images, DNA sequence and genotype files); organizing reagents for experimental work; writing short reports and experimental protocols; applying computational methods to analyze genetic data; and participating in lab group meetings, departmental seminars and relevant campus seminars.
The Specialist is expected to co-write manuscripts with the PI using data from his/her research projects. In addition, s/he is expected to perform a variety of technical support and routine lab jobs (ordering supplies, equipment maintenance, general lab organization and management).
The Junior Specialist is expected to perform experiments that investigate mechanisms of  vitamin A (retinol) transport and metabolism during embryonic stages of vertebrate eye, and  SOX3 dysregulation in vertebrate ocular, craniofacial and brain organogenesis. The specific duties include performing specific biochemical and molecular biological assays, and breeding mutant and transgenic mice to generate embryos suitable for analysis of anatomical and histologic defects and testing the resulting tissues with informative antigen markers. Findings will be presented in national and international conferences and published as peer-reviewed research article(s) in scientific journals.
The Junior Specialist is expected to study the current literature and attend scientific conferences, think critically and creatively, and meet with the PI on a regular basis (every 1-2 weeks) to formulate research hypothesis and design experiments. With assistance from the PI, the Junior Specialist will be executing experiments, collecting and interpreting the results first independently, and then discussing the results and conclusions with the PI. The Junior Specialist will formulate future hypotheses based on data obtained, and design or revise future experimental plans in consultation with the PI. The Junior Specialist is expected to gain a strong knowledge base about mammalian eye development, vitamin A metabolism, neurogenesis, and retinal cell fate changes through independent study and literature reading. The Junior Specialist will learn the rationales behind experimental procedures, creatively tailor protocols to our specific experimental conditions. The Junior Specialist will also independently and creatively troubleshoot any technical hurdles that may be encountered during the experiments.
2. PROFESSIONAL COMPETENCE AND ACTIVITY (10% EFFORT) The Junior Specialist will give oral or poster presentations at regional, national or international conferences, such as the West Coast Developmental Biology Meeting, and the Visual Systems Developmental GRC Meeting. They will also participate in all other associated activities of these conferences, such as career workshops. The Junior Specialist will likely become a member of the Society for Developmental Biology.
3. UNIVERSITY AND PUBLIC SERVICE (10% EFFORT) The Glaser lab has several undergraduate researchers and expects to recruit more in the coming years. We also periodically mentor Davis High School Biotechnology intern students. The Junior Specialist is expected to help in mentorship of these students. The Junior Specialist will also share expertise in mouse breeding and genetics, immunohistochemistry, histology and molecular techniques with other research groups in the department and/or university. BASIC QUALIFICATIONS:
Bachelor's degree in biology or a related field (Genetics, Biochemistry, Neuroscience or Physiology). Must have received bachelor's degree prior to start date
One year of research laboratory experience (required)
Experience in molecular biology assays such as (but not limited to) restriction-enzyme based ligation, subcloning, quantification of nucleic acids
Experience working with genetically modified mice that may include breeding mutant mouse lines and PCR genotyping
Experience in histology, preparation tissues for antibody labeling and/or microscope wild field or confocal imaging
Strong interpersonal, communication, and decision-making skills; as well as the ability to work well independently and as part of a team
Strong organizational skills that are needed to maintain databases of inventories and details of multiple simultaneous experiments
TERM OF APPOINTMENT: Full-Time (100%) appointment. Initial appointment is for 12 months; reappointment is pending satisfactory performance, needs of the research project, and sufficient funding.
TO APPLY: To apply, please go to the following link: https://recruit.ucdavis.edu/JPF03259 For full considerations applications must be completed by November 19, 2019; however, the position will remain open until filled through December 31, 2019.
Qualified applicants should submit:
Curriculum Vitae (CV)
Cover letter - detailing your qualification for this position
Contact information for 3 professional references
UC Davis commits to inclusion excellence by advancing equity, diversity and inclusion in all that we do. We are an Affirmative Action/Equal Opportunity employer, and particularly encourage applications from members of historically underrepresented racial/ethnic groups, women, individuals with disabilities, veterans, LGBTQ community members, and others who demonstrate the ability to help us achieve our vision of a diverse and inclusive community. For the complete University of California nondiscrimination and affirmative action policy see: http://policy.ucop.edu/doc/4000376/NondiscrimAffirmAct. If you need accommodation due to a disability, please contact the recruiting department.
Under Federal law, the University of California may employ only individuals who are legally able to work in the United States as established by providing documents as specified in the Immigration Reform and Control Act of 1986. Certain positions funded by federal contracts or sub-contracts require the selected candidate to pass an E-Verify check. More information is available http://www.uscis.gov/e-verify.
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