This position is available in the laboratory of Dr. Eric Schnell, at the Portland VA Medical Center / OHSU. Our laboratory studies synaptic physiology and the contribution of individual signaling molecules to the control of microcircuit function in both healthy and diseased brains. We are seeking a motivated and talented individual that is enthusiastic to perform hypothesis-driven research at the cellular and circuit level.
The primary purpose of this position is to study and characterize the role of specific genes and cell types in the pathogenesis of epilepsy. Experiments will utilize genetically modified mice in combination with live imaging, optogenetic, pharmacogenetic and electrophysiologic approaches to determine how inhibition or stimulation of selected subsets of hippocampal neurons controls neuronal circuit function. Most, but not all, approaches involve single-cell electrophysiology in acutely prepared brain slices, but live confocal imaging and EEG-based assessments of epileptic phenotypes are also in the near future. Must be willing to work with animals in all aspects of research.