The Department of Medicine, Division of Blood and Marrow Transplantation (BMT) is seeking a Life Science Research Professional 1 to perform cutting edge, interdisciplinary research in type 1 diabetes (T1D) and transplantation Immunology under supervision of the Research Technical Manager (RTM) and Principal Investigator (PI). The incumbent will perform experiments in defined research projects in type 1 diabetes (T1D) and transplantation immunology and will be assigned a portion of the research project(s) to handle independently. Research projects include: 1) immunofluorescent staining of immune cell subsets from humans and mice with or at-risk for T1D, and analysis of those subsets by flow cytometry, 2) sorting of immune cell subsets by FACS, 3) analysis of immune subset function in vitro and 4) perform in vivo studies including diabetes adoptive transfer, bone marrow and organ/tissue transplantation experiments. Research involves both the performance of immune cell functional assays and the development of others that assess cytokine production, and ability of B, T and myeloid cells to prevent alloimmune rejection of organ/tissue transplants and abrogate autoimmunity. The incumbent is expected to interpret/analyze results, assist in the cleaning/maintenance of the lab, biobanking, inventory of lab reagents/supplies, preparation of buffers/reagents, assist in the maintenance of the mouse colony, preparation of animal protocols (APLAC), develop new methods of purifying beta cell antigen proteins, and assist in compliance with EH&S regulations. Other duties may also be assigned.
The BMT program at Stanford performs autologous and allogeneic transplantations for over 300 patients each year. The program has been very successful with a history of limited morbidity rates and acute mortality that is well below most published reports. In addition to a successful clinical practice, our program researchers are translating their discoveries into new therapies, advancing the efficacy of hematopoietic cell transplantation for patients worldwide.
Plan approach to experiments in support of research projects in lab and/or field based on knowledge of scientific theory.
Independently conduct experiments; maintain detailed records of experiments and outcomes.
Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.
Review literature on an ongoing basis to remain current with new procedures and apply learnings to related research.
Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
Monitoring and analysis of experimental animals.
Cryopreserving cells and tissues from patients with or at-risk for T1D, establish and maintain inventory records of frozen cells/tissues and retrieve samples for distribution to members of the Meyer and other Labs.
*- Other duties may also be assigned
Bachelor's degree in the bio-sciences that includes related coursework. (Resume, CV, or cover letter should clearly reflect related coursework).
Experience in purification of immune cell subsets, isolation of DNA/RNA/Protein and performing cytokine secretion assays.
Experience in immunology research that includes immunofluorescent staining of human and/or mouse immune cells and analysis by flow cytometry to determine composition and subsets of cells; isolation and harvesting of immune cells and assays of immune cell function.
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
Ability to maintain detailed records of experiments and outcomes.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Ability to work under deadlines with general guidance.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working in close proximity to blood borne pathogens.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs.
Interpersonal Skills: Demonstrates the ability to work well with Stanford colleagues and clients and with external organizations.
Promote Culture of Safety: Demonstrates commitment to personal responsibility and value for safety; communicates safety concerns; uses and promotes safe behaviors based on training and lessons learned.
Subject to and expected to comply with all applicable University policies and procedures, including but not limited to the personnel policies and other policies found in the University's Administrative Guide, http://adminguide.stanford.edu/.
Location: School of Medicine, Stanford, California, United States Schedule: Classification Level:
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 9000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford University is an ...equal opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.