Grade: E FTE: 100% The Weinacht lab at Stanford School of Medicine is seeking a highly motivated, collaborative and well organized Life Science Research Professional (LSRP1) with interest in the stem cell biology, hematopoiesis, immunology and metabolism. Successful candidates will join the Department of Pediatrics, Division of Stem Cell Transplantation and Regenerative Medicine at Stanford School of Medicine. Our laboratory is interested in understanding the fundamental mechanisms that link hematopoietic stem cell fate/differentiation to metabolism. To do so, we study single gene mutations affecting hematopoietic stem and progenitor cell development that lead to severe human disease. We have engineered an advanced cellular model systems by CRISPR-Cas9 gene editing to model disease-causing immune and hematopoietic defects in primary human hematopoietic stem cells. Reticular dysgenesis (RD) is one of the most serious forms of severe combined immunodeficiency (SCID). Patients with RD suffer from a combined block in neutrophil and lymphocyte development. The disease is caused by defects in the mitochondrial enzyme Adenylate Kinase 2 (AK2). How defects in AK2 translate into the disease phenotype has long remained elusive. The LSRA will be a member of the research team that is dissecting the mechanistic basis of this fascinating disease on a cellular and molecular level to help elucidate the intricate interplay between cellular metabolism, oxidative stress and cell death in a state of health and disease. The LSRA will learn to generate and characterize CRISPR-edited stem and progenitor cells, acquire expertise in targeted differentiation techniques and develop/refine his/her repertoire of basic and advanced molecular, biochemical and cell biological techniques in order to investigate questions of metabolism, proliferation, differentiation and apoptosis. Studies may involve drugs, recombinant DNA, stem cells and murine models.
Our laboratory works in close collaboration with other laboratories on campus, particular in the Stem Cell Institute and the Bioengineering Department at Stanford University and beyond. Candidates with outstanding interpersonal competencies, intrinsic motivation and skills in molecular biology/cell biology/biochemistry/bioinformatics or related fields are encouraged to apply. The PI has a particular interest in cultivating the careers of young scientists to help them achieve their long-term professional goals. The candidate can expect individualized mentorship tailored to their personal career goals and a positive and goal-oriented work environment. The position can be adapted for an individual who is seeking hands-on scientific training before pursuing higher academic graduate education or for an experienced individual who is ultimately seeking an academic research scientist or scientific managerial position. Candidates must adhere to highest ethical principles when working with laboratory animals.
Plan and perform experiments in support of research projects in lab and/or field based on knowledge of scientific theory. Interpret and perform basic analyses of results.
Apply the theories and methods of a life science discipline to interpret and perform analyses of experiment results; offer suggestions regarding modifications to procedures and protocols in collaboration with senior researcher.
Review literature on an ongoing basis to remain current with new procedures and related research.
Maintain detailed records of experiments and outcomes.
Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
Help with general lab maintenance as needed; maintain lab stock, manage chemical inventory and safety records, and provide general lab support as needed.
Assist with orientation and training of new staff or students on lab procedures or techniques.
* - Other duties may also be assigned
Master's degree in Biology, Biochemistry, Chemistry, Molecular biology or other related life-science discipline
Proficiency in scientific writing in English
Exceptional attention to detail and meticulous execution and record keeping of experiments
Must be able to think critically and is encouraged to design experiments with guidance
Basic understanding of biological principles
Strong communication skills
Must adhere to highest ethical principles when working with laboratory animals
EDUCATION & EXPERIENCE (REQUIRED):
Bachelor's degree in related scientific field.
KNOWLEDGE, SKILLS AND ABILITIES (REQUIRED):
General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
Ability to maintain detailed records of experiments and outcomes.
General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
Ability to work under deadlines with general guidance.
Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
Rarely climb, scrub, sweep, mop, chop and mix or operate hand and foot controls.
Must have correctible vision to perform duties of the job.
Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
Ability to lift heavy objects weighing up to 50 pounds.
Ability to work in a dusty, dirty, and odorous environment.
Position may require repetitive motion.
*- Consistent with its obligations under the law, the University will provide reasonable accommodation to any employee with a disability who requires accommodation to perform the essential functions of his or her job.
May require working with blood or other mammalian tissues.
May require work in an environment where animals are used for teaching and research.
Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
May require extended or unusual work hours based on research requirements and business needs. Additional Information
Location: School of Medicine, Stanford, California, United States Schedule: Classification Level:
Stanford is an equal opportunity employer and all qualified applicants will receive consideration without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, veteran status, or any other characteristic protected by law.
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Located between San Francisco and San Jose in the heart of Silicon Valley, Stanford University is recognized as one of the world's leading research and teaching institutions. Leland and Jane Stanford founded the University to "promote the public welfare by exercising an influence on behalf of humanity and civilization." Stanford opened its doors in 1891, and more than a century later, it remains dedicated to finding solutions to the great challenges of the day and to preparing students for leadership in a complex world. The University's thriving diverse community is comprised of nearly 7000 undergraduate students, 9000 graduate students, 2000 faculty members, 1900 postdoctoral scholars, and over 11,000 academic and administrative staff in seven schools including several interdisciplinary research centers and institutes. The campus spreads over 8000 contiguous acres and nearly all undergraduates live on campus. Stanford offers bachelor's and master's degrees in addition to doctoral degrees (PhD, MD, DMA and JD) plus a number of professional and continuing education programs and certifications. More at http://facts.stanford.edu and http://www.stanford.edu. Stanford University is an ...equal opportunity employer and is committed to increasing the diversity of its faculty. It welcomes nominations of and applications from women, members of minority groups, protected veterans and individuals with disabilities, as well as from others who would bring additional dimensions to the university’s research, teaching and clinical missions.