The DeFranco laboratory is seeking to hire a scientist at the Associate or Full Specialist level to pursue a project designed to understand how genetic susceptibility can lead to spontaneous autoimmune disease, using a mouse disease model in which two distinct immunological tolerance mechanisms have been partially compromised by genetic mutation. 50% of these genetically identical mice exhibit a vigorous autoimmune attack on the retina, whereas 50% maintain immunological tolerance and are protected. The primary goal of the project is to determine the immunological mechanisms underlying the initiation of immune attack or protection from disease in the groups of mice with disparate outcomes. Studies will include flow cytometry, molecular cloning of T cell receptor genes from single cells and reintroduction into hematopoietic stem cells or lymphoid progenitors, mouse handling, mouse breeding, dissection of organs from euthanized mice, generation and analysis of histological sections of organs, injection of mice with cells, chemicals or vaccines, in vitro lymphocyte stimulation in tissue culture, and related methods.
Ph.D. degree in Immunology, Cell Biology, Molecular Biology, or related discipline
Two or more years experience in a research laboratory setting with immunological techniques, including flow cytometry and isolation of desired immune cell types
Two or more years experience in preforming experiments with mice or similar animal model
Two or more years experience with PCR, DNA sequencing, molecular cloning, gene transfection, and tissue culture
Some experience with protein biochemistry
Ability to plan activities to accomplish multiple goals in the same time frame
Demonstrated ability to work independently and as a member of a team
Demonstrated ability to obtain high quality research results leading to publication in peer-reviewed journals
Excellent interpersonal communication skills (verbal and written)
UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sexual orientiation, gender identity, national origin, disability, age, or protected veteran status.
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and high-quality patient care. It is the only UC campus in the 10-campus system dedicated exclusively to the health sciences.